Louisville travels to Clemson to take on a Tigers team that saw its College Football Playoff hopes eviscerated by Notre Dame last week. The Clemson offense was stuck in the mud against the Irish as head coach Dabo Sweeney refuses to accept the fact that his best quarterback has been standing next to him on the sideline in five-star recruit Cade Klubnik. Starter DJ Uiagalelei continues to be maddeningly inconsistent and is set to struggle against a Louisville defense ranked 10th in FBS by Football Outsiders. For Louisville, Malik Cunningham is dangerous outside the pocket but has not been effective through the air. Going on the road to Clemson won’t help. We were surprised to see the over-under in this game set at 52. Both teams lean on their defense and run games. This one goes under 52 points and we advise playing this now at Bookmaker as the total is ticking down in most places.